Coluracetam is a new member of the racetam family that has been shown to boost long-term memory. It also reduces depression and anxiety and enhances eyesight. It is believed to work by enhancing HACU sites and acetylcholine receptors.
It has also been shown to improve AMPA potentiation, which is important for learning and memory. It may also help people with schizophrenia and other metal disabilities.
Benefits
Coluracetam powder europe is a nootropic compound that is thought to help enhance cognitive function. It works by enhancing high-affinity choline uptake, or HACU. This process is the rate-limiting step in drawing choline into neurons for synthesis of the neurotransmitter acetylcholine. If this process is not working as it should, memory problems can arise. Coluracetam is also believed to improve AMPA potentiation, which boosts brain activity and motivation.
It is often used as a stacking supplement with piracetam and aniracetam, since it is thought to strengthen their effects. It is also a good choice for people with anxiety and depression since it can improve mood. It is also known to increase acetylcholine levels, which promotes mental clarity and focus.
It is a member of the racetam family and was initially developed by Mitsubishi Tanabe Pharma Corporation as an Alzheimer’s disease treatment. However, it did not reach the desired clinical endpoints in trials. The compound was then licensed to Brain Cells Inc, which developed it for major depressive disorder and general anxiety disorder.
Dosage
In a small dose, Coluracetam acts quickly to boost long-term and working memory. It also boosts focus and concentration. It is a great nootropic for anxiety and depression. It works by enhancing acetylcholine and reducing inflammation in the brain. It can even increase a person’s vision, and it has been reported to enhance colors and contrasts.
The compound is similar to piracetam but has an additional three-ring fluoroquinolone component bonded to the amide group at RN. This structure allows it to better modulate the choline transporter and increase high affinity choline uptake. This process is essential for the synthesis of acetylcholine, a neurotransmitter that plays an important role in memory functions.
Additionally, it has been shown to protect N-Methyl-D-aspartate (NMDA) receptors from glutamate toxicity. It also has some anxiolytic properties that improve mood and quieten anxiety. In addition, it appears to interact with AMPA receptors and may be a potential ampakine nootropic. This interaction is likely to cause a reduction in AMPA receptor toxicity and enhance long-term potentiation (LTP) in the brain.
Side effects
While most nootropics boost acetylcholine levels in the brain, coluracetam powder targets choline directly. Its primary function is to improve memory and learning by boosting the high-affinity choline uptake (HACU) process. However, it also has anxiolytic qualities that help reduce anxiety and depression. It also improves vision, increases motivation, and relieves irritable bowel syndrome.
In addition, it is fat-soluble and can be stacked with choline precursors like CDP-Choline or Alpha GPC to boost its cognitive enhancement effects. It is often taken sublingually, under the tongue, to maximize absorption. Some people experience a feeling of brain fog and lack of focus but this should subside with regular use.
Research shows that coluracetam promotes neurogenesis, a process that creates new brain cells and improves cognitive function. It does so by inhibiting NMDA receptors and increasing the activity of AMPA receptors. It may also be able to treat major depressive disorder and generalized anxiety disorder. Its anti-depressant effect may be related to its ability to increase acetylcholine and its effects on AMPA receptors.
Manufacturers
While most nootropics have been tested for a long list of potential benefits, Coluracetam is still relatively new. This is because it’s quite expensive to produce, and requires rigorous quality control in order to avoid toxic impurities.
It was first synthesized in 2005 by Mitsubishi Tanabe Pharmaceutical Corporation for use as an Alzheimer’s disease treatment. However, after failing to meet its clinical trials goals, it was licensed to BrainCells Inc, who conducted testing that showcased its potential as a medication to help alleviate the symptoms of major depressive disorder and anxiety.
The chemical structure of coluracetam is very distinct from other racetams, and it features a five-member nitrogenous pyrrolidine nucleus attached to an acetamide group through a benzyl and furan ring on either side. It enhances high-affinity choline uptake (HACU), the rate-limiting step in the conversion of choline to the neurotransmitter acetylcholine. Increasing the rate of HACU results in higher levels of acetylcholine, which is associated with improved cognitive function.
